Welcome to the latest episode (July 2026) of DOC Updates, where every month Neil Skolnik, MD and John Russell, MD review the most important articles on diabetes, obesity, and cardiometabolic disease.

This month on DOC Updates:

• Aroda V, Buzzetti R, Dalskov S et al. "Efficacy and safety of once-weekly cagrilintide–semaglutide (CagriSema) in adults with type 2 diabetes inadequately controlled on diet and exercise (REIMAGINE 1): a randomised, double-blind, placebo-controlled, phase 3a study." The Lancet Diabetes & Endocrinology, 2026; 0 doi: 10.1016/S2213-8587(26)00126-9

• Bajaj H, Welch M, Shah P et al. "Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial." The Lancet, 2026; 407, 2402-2413 doi: 10.1016/S0140-6736(26)00967-0

• Melville, N. "CGM Monitoring Benefits Extend to Non-Insulin-Using T2D." Medscape, June 07, 2026

• Aronne, L.J., Horn, D.B., le Roux, C.W. et al. "Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial." Nat Med(2026) doi: 10.1038/s41591-026-04386-7

• Salive ME, Tjaden AH, Ames JR, et al. "Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults With Prediabetes." JAMA. Published online June 15, 2026. doi:10.1001/jama.2026.8492

Presented by:

• Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

• John J. Russell, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Chair-Department of Family Medicine, Abington Jefferson Health

For information about the American Diabetes Association's scholarly journals, visit diabetesjournals.org. For more about this podcast, visit About Diabetes Core Update.

In this special edition of DOC Updates, Neil Skolnik speaks with Dr. Juan Frias, who catalogues the latest cardiometabolic medications, emphasizing the distinguishing characteristics of each.

This special episode is sponsored with support from Lilly.

Presented by:

Neil Skolnik, MD, Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

Juan Pablo Frias, MD, Medical Director and Principal Investigator, Los Angeles Institute for Metabolic Research, Adjunct Professor of Medicine at Charles Drew University of Medicine and Science

In this special episode of The Points of CARE, recorded live during the American Diabetes Association's (ADA) 2026 Scientific Sessions in New Orleans, hosts Richard Beaser, MD and Jane Reusch, MD highlight a new symposium on the clinical, social, and economic costs of treating—or not treating—individuals with obesity.

This panel discussion is moderated by Louis J. Aronne, MD, Sanford I. Weill Professor of Metabolic Research at Weill-Cornell Medical College in New York, former president of the Obesity Society, and chair emeritus of the American Board of Obesity Medicine.

Presenters:

• Timothy Dall, MS Managing Director for Life Sciences Consulting at GlobalData

• Melanie R. Jay, MD, Professor of Medicine and Population Health at the New York University Grossman School of Medicine

• Catherine Ferguson, MA, Vice President of Federal Advocacy for the ADA

Featured Articles:

• The Cost of Inaction in Treating Obesity in the U.S. doi.org/10.2337/doci25-0011

• Benefits and Costs of Treating Obesity Among Adults in Commercial Insurance Plans doi.org/10.2337/doci25-0006

• Estimating the Health, Economic, and Social Benefits of Obesity Treatment Using Microsimulation Modeling doi.org/10.2337/doci25-0004

For more on the Cost of Obesity collection, visit diabetesjournals.org/collection/26413/Cost-of-Obesity

To learn more about Diabetes, Obesity, and CardioMetabolic CARE please visit diabetesjournals.org/docm-care. Thank you for listening, and don't forget to subscribe.