Cancer’s Hidden Weakness Exposed | Science News
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Cancer’s Hidden Weakness Exposed | Science News
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Scientists have uncovered a hidden vulnerability in deadly cancers like small cell lung, prostate, and ovarian—tumors that lose the RB gene and become treatment-resistant. But here’s the breakthrough: these cancers desperately rely on E2F3 to survive. Blocking E2F3 kills them. Researchers at UCLA used advanced lab models to confirm this dependency across cancer types, and while no drugs target E2F3 directly, they found that inhibiting DHODH—a pathway already targeted by FDA-approved autoimmune drugs—can slash E2F3 levels and slow tumor growth. This could mean repurposing existing meds to fight aggressive cancers faster.
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