This episode does a deep dive into a study by Northwestern University researchers who examineed how extended overnight fasting (EOF), specifically ending meals at least three hours before sleep, impacts the health of middle-aged and older adults.

Grimaldi D, Reid KJ, Abbott SM, Knutson KL, Zee PC. Sleep-aligned Extended Overnight Fasting Improves Nighttime and Daytime Cardiometabolic Function. Arterioscler Thromb Vasc Biol. 2026;46(4):e323355. doi:10.1161/ATVBAHA.125.323355 [1, 2].

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This episode dissects the findings from the DO-HEALTH trial, a large-scale clinical study examining how vitamin D, omega-3, and exercise influence the biological aging of older adults.

Bischoff-Ferrari HA, Gängler S, Wieczorek M, et al. Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial. Nature Aging. Published online February 3, 2025. doi:10.1038/s43587-024-00793-y

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This episode dissects a systematic review and meta-analysis that evaluates the impact of exercise training on five key blood lipid markers to assist in the management of dyslipidemia.

Smart NA, Downes D, van der Touw T, et al. The effect of exercise training on blood lipids: a systematic review and meta-analysis. Sports Med. 2025;55:67-78. doi:10.1007/s40279-024-02115-z

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