Nasal DNA Vaccine Targets Hidden TB Bacteria | Science News cover art

Nasal DNA Vaccine Targets Hidden TB Bacteria | Science News

Nasal DNA Vaccine Targets Hidden TB Bacteria | Science News

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Scientists at Johns Hopkins have developed a groundbreaking nasal DNA vaccine that targets hidden TB bacteria, slashing treatment time and boosting existing drugs against resistant strains. By training immune cells to attack “persister” cells directly in the lungs, this spray-like therapy cleared infections faster in animal trials and prevented relapses. Early results in mice and monkeys show lasting immunity and reduced inflammation, offering hope for a future where TB treatment is shorter, more effective, and accessible — especially as drug-resistant cases rise globally.

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