Doctor and special correspondent Avir Mitra takes Executive Editor Soren Wheeler, plus a live studio audience, on a journey from the operating room to inside the body to the farm to the sewers and back again—searching for answers to an alarming threat to humanity’s existence as we know it: antibiotic resistance in bacteria.

This live show, performed in New York City and also in Little Rock, Arkansas, is part of a series we’re doing with Avir that we are calling “Viscera.” Each event is a conversation that takes the audience on a journey into a quirk or question or mystery inside of us, and gives them a visceral experience of the viscera within us. The previous installment of the series was called “The Elixir of Life.” (https://radiolab.org/podcast/the-elixir-of-life)

Special thanks to all of Little Rock Public Radio (especially Grace Zafasi and Jonathan Seaborn), Thomas Patterson, The Greene Space staff, CALS Ron Robinson Theater, Tom Philpott, Stephen Roach, Kate Shaw, Alex Wong, Maryn McKenna, and Kerri McClimen.

The video version of this performance will be available soon on our Youtube Channel, playlist Radiolab Presents: Viscera. Till then, you can check out our other episodes in the Viscera series.

EPISODE CREDITS:
Reported by - Avir Mitra
Produced by - Jessica Yung
Sound design contributed by - Jeremy Bloom and Jessica Yung
Fact-checking by -Natalie Middleton

EPISODE CITATIONS:

If you are a patients or a doctor, and you are interested in phage therapy, reach out to Dr. Steffanie Strathdee at IPATH@ucsd.edu

Videos:

• Check out the video from the Viscera live show (and a bonus Q&A with Bruce Stewart-Brown and Steffanie Strathdee) on Radiolab’s YouTube.
• A deep dive (https://zpr.io/3iAj47RyzFRY) on bacteriophages with Avir Mitra and Steffanie Strathdee, also on Radiolab’s Youtube.

Books:

• The Perfect Predator (https://theperfectpredator.com/) by Dr. Steffanie Strathdee’s telling of her battle against a killer superbug.
• Plucked (https://zpr.io/PudGMEuzgU9X) by Maryn Mckenna a detailed accounting of chicken farming’s practice of using antibiotics.

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Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.

Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.

A strange brew that's hard to resist, even for a modern day microbe.

In the war on devilish microbes, our weapons are starting to fail us. The antibiotics we once wielded like miraculous flaming swords seem more like lukewarm butter knives. But in this episode, originally released in 2015, we follow an odd couple, of a sort, to a storied land of elves and dragons. There, they uncover a 1,000-year-old secret that makes us reconsider our most basic assumptions about human progress and wonder: what if the only way forward is backward?

Special thanks to Steve Diggle, Professor Roberta Frank, Alexandra Reider and Justin Park (our Old English readers), Gene Murrow from Gotham Early Music Scene, Marcia Young for her performance on the medieval harp and Collin Monro of Tadcaster and the rest of the Barony of Iron Bog.

Can’t get enough of that sweet, sweet antibiotic resistance content? Then you’ll be over the moon about next week’s release. It’s the podcast cut of our most recent installment of our live show series called Viscera. This one features executive editor Soren Wheeler and Avir Mitra, and it’s all about how our millenia's-long war against bacteria came to a tipping point in this modern age.

Subscribe or follow our show on your favorite streaming platform and you’ll be the first to know when it drops.

EPISODE CREDITS:
Reported by - Latif Nasser
Produced by - Matt Kielty and Soren Wheeler

EPISODE CITATIONS:
Articles -
Uncovering the multifaceted mechanism of action of a historical antimicrobial (https://zpr.io/mucw6Td6LBxT) by Harrison, F et al, 2026 bioRxv (PREPRINT). In this article Freya and her team describe the mechanisms under which Bald’s Remedy actually works.

Signup for our newsletter!! It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!

Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.

Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing radiolab@wnyc.org.

Leadership support for Radiolab’s science programming is provided by the Simons Foundation and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.