Dr. Uri Alon is a physicist-turned-biologist, a professor at the Weizmann Institute, and one of the leading thinkers exploring how complex biological systems work. In this episode, we discuss his research on the effects of genetics, lifestyle, environment, and luck on human lifespan.

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Timestamps:

00:00 Intro

00:55 How big of a role does genetics play in longevity

06:25 How important is lifestyle vs genetics

08:25 How big of a role does lifestyle play in longevity

12:55 Why is lifestyle less impactful than genetics

15:25 Bon Charge sponsorship

16:30 Genes of people who live to 110

18:55 Why lifestyle matters a lot if you have bad genes

21:45 What leads to aging

22:45 What’s the maximum human lifespan

25:20 Why nobody has lived over 122 yet

27:05 Strategies to extend lifespan beyond normal

34:05 What made Uri interested in longevity as a physicist

36:25 Recurring patterns in human longevity and aging

38:40 Simplest analogie for aging

49:15 Surprising role of luck in longevity

54:55 How to practically extend your lifespan

59:30 What Uri needs to discover next about aging

Dr Uri Alon Lab YouTube channel with Systems Aging courses: https://www.youtube.com/@alonlab9733/videos

My 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course

P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

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Timestamps:

00:00 Intro

00:36 Lifestyle bracket

06:50 Lifestyle bracket winners

11:47 Join my online community

18:46 Medicine / pharmaceutical bracket

19:20 Medicine /pharmaceutical bracket winners

22:32 Geroscience bracket

33:13 Geroscience winners

35:00 Biohacking bracket

40:16 Biohacking bracket winners

43:04 Final 8 winners

46:32 Final 4 winners

49:23 Final 2 winners

Vote yourself for the Longevity Bracket: https://www.optispan.life/longevity-bracket

My 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course

Professor Michael Crawford is a renowned scientist and Director of the Institue of Brain Chemistry and Human Nutrition in Imperial College London. He’s known for his research demonstrating the essential role of omega-3s specifically DHA in brain development and human evolution. He’s been pioneering this research since the 70s and he’s 95 years old himself.

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Timestamps:

00:00 Intro

01:00 How Dr Crawford started researching DHA and omega-3s

04:00 Relationship between DHA and brain structure across species

07:00 How DHA drove the evolution of the human brain

12:20 Did humans evolve because of hunting land animals or consuming seafood

16:10 How a waxy fatty layer covering human babies makes us so different from other land animals

19:50 Bon Charge sponsorship

20:50 How the early stages of human brain evolution might have looked like

24:20 Why did DHA allow our brains to develop so well

27:20 Declining IQ and brain health conditions

31:00 Behavioral disorders and DHA

34:05 Iodine and other nutrients for brain development

36:55 Dr Crawford’s amazing cognition at the age of 95

39:20 How much DHA would people need per day

41:40 Is fish high in heavy metals

46:40 Omega-3s from meat

50:20 Plant-based omega-3s

51:20 Bottleneck for cranial capacity for land animals

54:55 Supplementing vs eating seafood

56:20 Omega-6 vs omega-3s

57:30 What needs to be done for fixing nutrition

01:03:30 Can you catch up with lost brain development

01:06:00 Are omega-3s easily oxidized

01:07:35 Advice for young researchers

01:10:05 Dr Crawford’s book

My 2026 longevity routine: https://youtu.be/OceysodInIo

100 supplements ranked: https://youtu.be/W8DZbYyuDmA?si=-QhWReblSJGdNoyi