Dr. Alexis Ortega is board-certified in longevity, regenerative and aesthetic medicine. He has a clinic Ad Astra in Barcelona, Spain.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

00:55 How to counteract age-related loss of facial harmony aside from just wrinkles

12:30 Does growth hormone change the face

18:10 Bon Charge sponsorship

19:17 What's the minimum effective dose of at-home skincare — the three things that actually move the needle?

21:28 Retinoids

24:05 Skin barrier support

27:00 Effect of sun exposure on extrinsic skin aging

31:02 Best evidence-based sunscreen ingredients

34:34 List of best sunscreen ingredients

36:00 Worst sunscreen ingredients

37:45 Daily sunscreen vs using the UV index as a guide

39:43 Do people overuse skincare products

42:33 Castor oil, beef tallow and egg yolks for skin

49:08 Are natural sunscreens effective

49:59 If someone had unlimited money today, what are the most promising rejuvenation interventions actually available?

51:08 What diagnostics Alexis would do with an unlimited budget

54:30 Rejuvenation therapies Alexis would do

55:18 Alexis approach to peptides

56:00 Intravenous senolytics

56:20 NAD injections

57:14 What you can do now to practically extend lifespan

59:40 Intravenous exosomes

01:00:25 Therapeutic plasma exchange

01:03:06 Stem cell therapy

01:05:30 Gene therapies

01:07:48 What biomarkers matter most for predicting long-term health

Alexis Ortega MD Instagram: https://www.instagram.com/alexis_ortega_md/

Dr. Kevin Perez is a computational biologist working at the cutting edge of aging science and drug discovery. His work focuses on aging research, drug repurposing, and integrating complex multi-omics data to better understand how we can extend healthspan.

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland

Timestamps:

00:00 Intro

00:47 Kevin’s study about pharmaceuticals that are associated with reduced mortality

10:17 Which class of drugs had reduced mortality

13:07 Bon Charge sponsorship

14:12 How Kevin researches longevity molecules

16:37 Estrogen’s longevity effects

17:37 How Kevin started researching dog aging

25:32 Chemical reprogramming

29:32 Kevin’s understanding of what causes aging

34:52 Metformin vs SGLT2 inhibitors

38:37 Erectile dysfunction drugs

43:02 Over the counter supplements with longevity effects

45:52 Biological age clocks

50:02 What Kevin thinks is the best biomarker of aging

54:32 Composite biological age vs combination of multiple markers

59:32 Kevin’s new study plans

01:02:52 What Kevin wishes he adopted sooner

Start rewinding your biological clock: https://www.siimland.co/course

P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Join our LONGEVITY Community: https://www.skool.com/longevity-society

Timestamps:

00:00 Intro

00:37 Why Brad crowd funded a rapamycin trial

03:22 What Brad’s rapamycin trial found

12:57 Why rapamycin blunted the effects

17:17 Rapamycin effects on grip strength

19:57 Rapamycin and immune effects

21:47 Effects on biomarkers

25:22 Brad’s thoughts on rapamycin moving forward

31:52 Metformin exercise effects

32:52 Other medicines with longevity potential

36:37 Medicines that move the needle the most for people

45:17 Will Brad do another study

48:27 Brad on GLP-1s

Dr Brad Stanfield is a family medicine doctor in New Zealand: https://www.youtube.com/@DrBradStanfield

Bloodwork for longevity panel discussion: https://youtu.be/7QONBQCpRJ0

My 2026 longevity routine: https://youtu.be/OceysodInIo

Start rewinding your biological clock: https://www.siimland.co/course