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The Health Edge: translating the science of self-care

The Health Edge: translating the science of self-care

By: Mark Pettus MD and John Bagnulo PhD MPH
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“It’s not what we don’t know that gets us into trouble. It’s what we know that ain’t so”.

Will Rogers


We believe the explosion of life science research from many disciplines had catapulted ahead of our capacity to process, integrate, understand, and apply. We are interested in translating all that is out there as news to use. A fundamentally different understanding of human biology has emerged. The implications from the perspective of self-care are profound. We are rapidly moving away from the debate of nature versus nurture toward an understanding that life emerges from a dynamic landscape of nature via nurture.

We are passionate about the science. We are passionate about the implications. We believe in the capacity and possibility made possible by being alive here and now! We are beautifully designed to be on the African Savannah, living fully integrated with our planet, and in the context of social relationship. Our modern environment is not well designed to promote human health and the capacity to thrive. Many are struggling to maintain balance and traction in lives that often feel overwhelming and frightening.The challenge is to better leverage our superb ancestral adaptation for a different and radically challenging modern environment. Everything that touches us today has the potential be be very familiar or totally foreign. The less aware one is of the day to day distance between what we are biologically , as a species, “familiar with” and what we actually encounter, the fewer the possibilities for more effective alignment.

Leaving one’s health trajectory to chance in our modern environment is a very risky proposition. We are interested in holding the science to the light with an open and humbled mindset. Like you, We are intrepid explorers interested in how we emerge in the midst of our relationship with the environmental inputs of our lives…how we eat, how we move, how we sleep, how we navigate the mind fields of conflict in our lives, how socially connected we are, how we manage the burden of environmental toxins in our lives, how much meaning we cultivate in our work, love, play and how we interpret and respond to stress in our lives. We will drill deep, share all that my experiences has taught and do all that we can to create value for you as you seek to find your health edge. We always welcome your feedback.

Mark and John

© 2026 The Health Edge: translating the science of self-care
Alternative & Complementary Medicine Hygiene & Healthy Living Physical Illness & Disease
Episodes
  • How Bile Acids Shape Appetite Metabolism And Detox
    Jun 3 2026

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    Bile might be the most overlooked substance in everyday health, yet it sits at the crossroads of digestion, detoxification, and metabolic control. We take a fresh look at bile quality and bile acids, starting with what the liver makes from cholesterol, what the gallbladder stores, and what gets released when we eat, especially after higher fat meals. From there, the story gets far more interesting: bile acids don’t just help you absorb fat, they also communicate with receptors in the gut and throughout the body in ways that can affect appetite, energy expenditure, insulin sensitivity, lipid patterns, and inflammation.

    We also unpack enterohepatic circulation, the recycling loop where roughly 95% of bile acids can be reabsorbed and sent back to the liver. That matters for anyone thinking about detoxification, because bile is a major exit route for fat-soluble toxins, and without the right binders those compounds can circle back. We talk through the practical role of soluble fibre, including beta-glucan and pectin, and why the source matters when you’re balancing bile binding with blood sugar control.

    The gut microbiome is the other half of the equation. Your bacteria convert primary bile acids into secondary bile acids, and that conversion can shift bile toward more inflammatory or more protective effects. We connect modern dysbiosis drivers like low fibre intake and antibiotic exposures with downstream bile changes, then get specific about foods that support thinner bile (extra virgin olive oil, flax, black seed oil, oily fish, avocado, nuts) and foods that often do the opposite (refined carbs and fried oils heated to high temperatures). If you’ve ever wondered why fried meals so often precede gallbladder pain, we explain the mechanism in plain language.

    Subscribe for more science-based self-care, share this with someone who struggles with gut issues or gallbladder symptoms, and if it helped, leave a quick review so more people can find the show.

    For slides and open source references: www.thehealthedgepodcast.com

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    45 mins
  • Sun Benefits By Using Sensible Exposure Patterns And Cleaner Sunblock
    May 6 2026

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    Sunscreen advice usually comes as a binary: fear the sun or ignore the risks. We take a different path and give you a practical framework for sun protection that doesn’t sacrifice the real health benefits of sunlight. From the start, we separate the roles of UVA and UVB so you can understand what actually causes sunburn, what drives vitamin D production, and why UVA is linked with skin aging while still playing a role in nitric oxide release and circulation.

    Then we get concrete about “sensible sunlight exposure,” a balanced approach popularised by vitamin D researcher Dr Michael Holick. We talk about how timing, latitude, altitude, season, and skin pigmentation change your safe window for unprotected sun, and why regular gradual exposure can build a “solar callus” that improves tolerance. We also cover a detail many people miss: most household glass blocks UVB but allows UVA through, which matters for anyone spending long hours near windows or on the road.

    Finally, we tackle sunscreen safety and label reading. We discuss concerns around common sunscreen chemicals like parabens and benzophenone-3 (often called oxybenzone), the reality of transdermal absorption with frequent reapplication, and why combining products can amplify exposure, especially when sunscreen overlaps with insect repellent. We share how we use the Environmental Working Group (EWG) tools like the Skin Deep app, clarify what SPF and “broad spectrum” really mean, and name the mineral sunscreens we trust, with an emphasis on zinc oxide and non-nano options.

    If this helps you rethink your summer routine, subscribe, share the show with a friend, and leave a review so more people can find smarter, safer guidance on sunlight, sunscreen, and skin health.

    Environmental Working Group: ewg.org

    www.thehealthedgepodcast.com

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    48 mins
  • A Practical Guide To Choosing Supplements
    Apr 29 2026

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    Your supplement shelf can turn into a silent monthly subscription, and the scariest part is not the cost. It’s the uncertainty. We sit down to unpack why supplements so often feel like a black box, how isolated nutrients can behave differently than nutrients in whole foods, and what a sensible, evidence-based supplement routine looks like when you care about real outcomes like strength, metabolic health, energy, and long-term resilience.

    We walk through the decision filters we use as clinicians, starting with the most straightforward case: measured deficiencies you can actually track, like vitamin B12 or vitamin D. From there, we share John’s “Four I’s” checklist (imbalance, insufficiency, infection, isolation) and why the food matrix matters so much when you’re deciding between a capsule and a plate. We also get specific about common scenarios, including vegan and plant-based nutrient gaps (especially zinc and B12), aging and fatty acid needs, and why omega-3 fish oil studies can look mixed compared with the consistent benefits of eating oily fish.

    We dig into risks that don’t get enough airtime, including supplement overload, vitamin toxicosis concerns, and medication-driven nutrient depletion. Metformin and B12, statins and CoQ10, and proton pump inhibitors and mineral absorption all come up, along with a bigger theme: changing a biomarker is not the same as improving an outcome. To keep things grounded, we share what we actually take right now, why creatine has one of the strongest evidence bases in sports nutrition and healthy aging, how creatinine lab values can be misread, and where berberine and targeted probiotics like Akkermansia may fit for metabolic health when paired with lifestyle changes. We close with practical tips on supplement quality and third-party testing, plus how to build a short-term “bridge” plan with clear stop rules.

    Subscribe for more evidence-based self-care, share this with someone whose cabinet is overflowing, and if you found this helpful, leave a review and tell us what supplement you want us to break down next.

    For video recording and open source reference articles: www.thehealthedgepodcast.com

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    52 mins
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