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Why do so many people with Lyme disease test "negative" — even while their symptoms keep getting worse?

In this episode of Pod of Inquiry, we sit down with functional medicine practitioner Dr. Pamela Cipriano, DNP, APRN, to uncover the hidden layers of chronic Lyme disease, mold toxicity, biofilms, heavy metals, and immune dysfunction that conventional medicine often overlooks.

Dr. Cipriano was the first nurse practitioner in Connecticut to open a solo practice and trained directly under renowned Lyme specialist Dr. Richard Horowitz. Together, they explore why standard Lyme testing frequently fails, how Borrelia bacteria evade antibiotics through biofilms and cyst forms, and why addressing mold exposure and toxic burden may be essential before treatment can truly work.

You'll also hear the controversial history surrounding Lyme disease, including Plum Island, Willy Burgdorfer, and insights from Kris Newby's book Bitten — plus emerging research on nattokinase, serrapeptase, Stevia, natural killer cells, and the functional medicine protocols gaining attention among integrative clinicians.

In this episode, we cover:
🦠 Why Lyme disease tests can produce false negatives
🧬 HNK1 (CD57) natural killer cell testing explained
🛡️ Biofilms, Borrelia cyst forms & antibiotic resistance
🌿 Stevia & serrapeptase research from Dr. Eva Sapi
☣️ Mold toxicity, heavy metals & detox sequencing
🫀 Nattokinase and coronary plaque research
📖 The controversial origins of Lyme disease
💉 Antiphospholipid syndrome & COVID vaccine decisions
🧠 Functional medicine approaches to chronic illness

If you've struggled with chronic fatigue, brain fog, unexplained inflammation, autoimmune symptoms, or suspect there's more beneath the surface of "mystery illness," this conversation may change the way you think about chronic disease entirely.

👍 Like, subscribe, and share if you enjoy deep conversations that challenge conventional thinking and explore the science behind chronic illness.

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Visit our website https://podofinquiry.com/latest-episodes/ - click on the show link to read the show notes and get more information.

Timestamps:
00:00 – Introduction & Dr. Pamela Cipriano
01:13 – Building a Functional Medicine Practice
05:19 – The Functional Medicine Mindset
08:42 – Heavy Metals, Mold & Multi-System Dysfunction
12:16 – Sequencing Treatment in Complex Cases
17:36 – The Lyme Disease Deep Dive
21:00 – The HNK1 (CD57) Test Explained
22:53 – ILADS vs. IDSA: The Lyme Debate
25:32 – The Combination Lyme Protocol
28:56 – Nattokinase & Coronary Plaque
33:51 – Plum Island & Lyme Origins
37:19 – COVID, Vaccines & Antiphospholipid Syndrome
43:37 – Where to Find Dr. Cipriano

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#LymeDisease #FunctionalMedicine #ChronicIllness #MoldToxicity #HeavyMetals #Biofilms #TickBorneIllness #Nattokinase #IntegrativeMedicine #DrPamelaCipriano