What is GLP-1 microdosing, and can smaller doses of medications like Ozempic, Wegovy, and Zepbound lead to better long-term weight loss results?

In this episode, registered dietitian Zoe is joined by Deidre, FNP, to break down one of the biggest conversations in obesity medicine right now: GLP-1 microdosing. They explain how microdosing differs from standard manufacturer dosing, why FDA-approved dosing schedules are designed for clinical trials, and why a one-size-fits-all approach may not work for every patient.

Deidre explains how slower, smaller dose increases may help reduce side effects like nausea and abdominal discomfort, while still supporting hunger control, fewer cravings, less food noise, and gradual weight loss. They also discuss super responders, non-responders, compounded medications, and why personalized GLP-1 dosing can make a major difference in long-term maintenance.

They also unpack the debate around GLP-1 microdose marketing, including the recent dispute involving Eli Lilly, Noom, and tirzepatide, and what it means for patients navigating telehealth weight loss programs.

Most importantly, Zoe and Deidre explain why medications are only one part of obesity treatment. Sustainable weight loss still depends on nutrition, whole foods, protein, fiber, lifestyle changes, and long-term support.

What happens to bariatric surgery when GLP-1 medications like Ozempic, Wegovy, and Zepbound change the entire weight loss landscape?

In this episode, Dr. Matthew Weiner and registered dietitian Zoe unpack what they saw at the 2026 ASMBS annual conference - a meeting that felt very different from prior years. Surgical volumes are down, many bariatric surgeons are wrestling with what GLP-1s mean for their practices, and patients are left trying to figure out whether medication, nutrition, surgery, or some combination makes the most sense.

Dr. Weiner explains why bariatric surgery still matters, but no longer belongs in the same place in the treatment sequence. For many patients, a GLP-1 trial should come first. For others, especially non-responders, patients with severe diabetes, or people losing mobility, surgery may be the safest and most effective next step.

They also discuss why low-dose GLP-1s may be more sustainable than high-dose treatment, how to recognize a medication non-response, and why the best obesity care in 2026 combines nutrition, medication, surgery, and long-term support instead of forcing patients into one silo.

What if your struggle with weight loss isn't about willpower at all, but about brain patterns you were born with? In this groundbreaking conversation, Dr. Matthew Weiner and registered dietitian Zoe sit down with neuroscientist Dr. Steve Rondeau, who has conducted over 50,000 EEG brain scans and just released his book Think Like a Brain. Dr. Rondeau reveals that emotional eating, stress eating, and food cravings aren't character flaws—they're measurable brain patterns that show up differently in every person. His research has identified that what we call "stress eating" can manifest in 4,096 different combinations of brain patterns, explaining why the same diet works for one person but fails for another.

One of the most exciting revelations is the potential to use brain scans to predict who will respond to GLP-1 medications like Ozempic, Wegovy, and Zepbound before they even take their first dose. Dr. Rondeau discusses the "overwhelmed pattern"—a specific brain biomarker where brain activity slows down under stress, strongly correlated with using food as an escape mechanism. He draws fascinating parallels between GLP-1 medications and psychedelic therapy, explaining how both create a window of opportunity where the usual noise quiets down enough for real behavioral change to happen. The key is using that window effectively with proper integration work.

This episode challenges the entire foundation of mental health diagnosis, revealing why the DSM is fundamentally flawed and how brain scan technology can finally match treatments to individual biology rather than broad symptom categories. Dr. Rondeau uses the powerful analogy of a husky in the desert versus the mountains—your brain patterns may be perfectly adapted for certain situations but set you up for failure in others. The conversation explores emerging wearable EEG technology, the inheritance of brain patterns, and the future of truly personalized medicine. Essential listening for anyone who has ever wondered why willpower never seems to be enough.

Connect with Dr. Steve Rondeau:

• Book: Think Like a Brain (thinklikeabrain.com)
• Available on Amazon, Barnes & Noble, and all major platforms
• Audiobook coming soon

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