Brady and Thomas delve into antioxidants, reviewing the ISSN's recent position statement on antioxidants: benefits, drawbacks, and reviewing supplements by efficacy

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00:00 Introduction

01:30 The role of antioxidants

05:05 Where we get antioxidants from

06:50 Hard training and antioxidant needs

08:55 Hormesis effect, risk of ‘blunting’ adaptation

12:47 AD ProBio Nutrition

15:00 Introducing the ISSN Supplement List

17:44 High Evidence (Creatine, Beetroot, Tart Cherry)

23:10 Moderate Evidence (Omega-3, Astaxanthin, Blackcurrant)

27:20 Lower Evidence (Ashwagandha, Glutathione, Green Tea, Pomegranate)

35:00 Weak-Low Evidence (Urolithin-A, Sulforaphane, Curcumin)

38:42 Takeaways - When Runners Should Take Antioxidant Supplements

39:00 Post-marathon antioxidants

40:41 Multi-day hard exercise antioxidants

Brady’s article on the discussion:

https://runlongrunhealthy.substack.com/p/should-runners-take-antioxidant-supplements

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Brady explains a new study that looks at the effect that endurance exercise has on the brain, both during and after exercise - and the potential implications for how runners should think about the post-run window.

00:00 The brain’s role in running

02:00 Describing the study: measuring brain activity during

05:40 findings: What happens in the brain during and after exercise

13:10 ProBio Nutrition (ad)

14:29 Does this work in humans? And neurodoping

16:05 Takeaways for runners: allow a window for recovery

20:18 Can we hack the brain?

Brady’s article on the discussion:

How Exercise Hardwires the Brain for Endurance

https://www.physiologicallyspeaking.com/p/physiology-friday-306-how-exercise

The study:

Exercise-induced activation of ventromedial hypothalamic steroidogenic factor-1 neurons mediates improvements in endurance

https://pubmed.ncbi.nlm.nih.gov/41687612/

Run Long Run Healthy is brought to you by Marathon Handbook.

➡ https://marathonhandbook.com

Subscribe to the Run Long Run Healthy podcast:

➡ Spotify: https://bit.ly/RLRH-spotify

➡ Apple podcasts: apple.co/43iqUKx

Get the RLRH weekly newsletter (choose free or paid):

➡ https://marathonhandbook.com/run-long...

➡ https://runlongrunhealthy.substack.com/

Follow us online:

BRADY ON X ➡ https://x.com/B_Holmer/

PHYSIOLOGICALLY SPEAKING (Brady's Newsletter) ➡ https://www.physiologicallyspeaking.com/

MARATHON HANDBOOK IG ➡ / marathon.handbook

Brady Holmer sits down with Dr. Marc Bubbs — performance nutritionist, author, and creator of ProBio Nutrition — to break down everything runners need to know about gut health. From identifying food triggers to fueling on race day without GI disaster, Dr. Bubbs shares 20+ years of experience working with Olympians, pro athletes, and everyday runners. Whether you're dealing with chronic bloating or trying to push your carb intake past 60g/hour, this episode has you covered.

Brought to you by ProBio Nutrition - your all-in-one daily supplement for runners. Get 40% off with code RLRH (or 50% off + free shipping with a subscription) ➡️

https://bit.ly/ProBioRLRH

📚 Dr. Bubbs' books: Peak and Peak 40

🌐 drbubbs.com | probionutrition.com

📱 Follow Dr. Bubbs on Instagram & YouTube: @drbubbs

0:00 Introduction & Dr. Mark Bubbs' Background

1:07 Crossover Between Elite Athletes & General Population

2:04 Gut Health as a Buzzword — What Does It Actually Mean?

2:47 The 4 Pillars of Good Gut Health (King's College Framework)

5:47 Three Gut Health Scenarios: Poor → Good → Great

6:19 Scenario 1: Red & Yellow Flags — When to See a Doctor

9:14 The Difficulty of Identifying Problem Foods

9:54 Exercise-Related vs. Everyday GI Symptoms

11:42 Why You Should Start With Breakfast

12:07 The 3-4 Hour Detective Method

13:59 Can GI Symptoms Actually Be Resolved?

15:02 Eating Out vs. Cooking at Home

16:09 Are Food Sensitivity Tests Worth Your Money?

18:37 Scenario 2: When Running Triggers GI Distress

19:48 How Getting Fitter Improves Gut Diversity

20:57 GI Symptom Rates: Ultras, Ironman, Team Sports & Running

22:50 Finding Your Carb Intake Inflection Point

24:17 Gut Training: Titrating Up From 60g/hr

25:36 Is Pushing Above 80g/hr Worth the Risk?

26:00 Fueling Advice for Slower Marathon Runners

26:56 — AD BREAK —

28:08 Best Ways to Train Your Gut

29:06 Race Day Anxiety & the Gut-Brain Connection

31:20 Building Gut Health Over Months of Training

31:41 The 30 Food Diversity Challenge

33:08 Does Getting Fitter Reduce GI Symptoms? (The Bell Curve)

35:12 Probiotics for Colds, Travel & Performance

36:30 Race Week & Race Morning: What to Do and Avoid

38:47 Pro Tip: Caffeinated Gum Before the Start Line

39:06 The Golden Rule — Don't Try Anything New on Race Day

39:30 Carb Mouth Rinsing: The Placebo That Works

40:00 Scenario 3: Optimizing Gut Health for Performance

41:08 Prebiotics Explained — Seeds for Your Gut Garden

43:47 Best Whole Foods for Gut Health (By Category)

46:28 The Truth About Processed Food & Your Gut

47:47 Knowledge vs. Execution: The Real Friction Point

49:00 ProBio ProBlend: Why Dr. Bubbs Created It

53:00 Where to Find Dr. Bubbs, His Books & ProBio